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Selected Publications (*, Corresponding Author) 

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  • Hu D, Sun XY, Shang YT, Lundberg K, Adams D* and Qi X*., A small-molecule stabilizer of the Calpastatin-Calpain-2 complex restores mitochondrial function and mitigates Neurodegeneration. Science Advances, 2026 Mar 27;12(13):eaeb1174. PMID: 41894510. 

    • Small Molecule Restores Mitochondrial Function and Reduces Neurodegeneration in HD Models, Rare Disease Advisor, April 2026. 

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  • Baron C#, Wang RH#, Cooke S, Ng HP, Ferreira RS, Miranda HC and Qi X*., TDP-43 Impairs Glycolysis by Sequestering Hexokinase 1 in Amyotrophic Lateral Sclerosis. Acta Neuropathologica, 2026 Mar 16;151(1):26. PMID: 41838122. #, co-first author 

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  • Hu D, Sun XY and Qi X*,  Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models. Molecular Neurodegeneration, 2025 Dec 22;20(1):126. PMID: 41430713 

    • Media Report- Scientists identify hidden protein interaction driving Parkinson’s disease, Science Daily, The Daily/CWRU; Researchers discover a biochemical route that plays role in Parkinson's disease, News Medical Life science 

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  • Choi W#, Fattah M#, Shang YT#, Thompson MP, Carrow K, Hu D, Liu ZR, Avram M, Bailey K, Berger O, Qi X* and Gianneschi NC*, Mutant Huntingtin Mimetic Protein-like Polymer Blocks Mitochondrial damage, Rescues Huntington’s Neurons, and Slows Onset of Neuropathology In Vivo. #, co-first author. *, co-corresponding author. Science Advances, 2024, Nov 1, 10, eado8307. PMID: 39485846

    • Media Report- New Huntington’s treatment prevents protein aggregation- EurekAlert AAAS. Polymer Therapy Shows Promise Against Huntington’s Disease- Neuroscience News, Genetic Engineering and Biotechnology News, Technology Network

    • New Approach to Fight Huntington's Disease Shows Early Promise- US News and World Report 

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  • Sridharan PS, Miller E, Kee T, Chakraborty S, Hu D, Tripathi SJ, Koh Yeojung, Chaubey K, Dhar M, Vazquez-Rosa E, Shin MK, Alvarado RA, Barker S, Franke K, Cintron-Perez CJ, Flanagan M, Castellani RJ, Gefen T, Wilson BM, Fujioka H, Woo JA, Kang D, Paul BD, Qi X* and Pieper AA*, Early transient inhibition of excessive mitochondrial fission after brain injury blocks transition to chronic neurodegenerative disease. *, co-corresponding author. Cell Reports Medicine, 2024 Sep 17;5(9):101715, PMID: 39241772

    • Media Report- New study shows that chronic neurodegeneration can be prevented after traumatic brain. –Newswise, The Daily, Spectrum News, Medical Press​

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  • Zhao YY, Hu D, Wang RH, Sun XY, Ropelewski P, Hubler Z, Lundberg K, Wang QQ, Adams D, Xu R and Qi X, ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models by impairing brain cholesterol turnover. Nature Communications, 2022 Mar 2;13(1):1121.  PMID: 35236834 

    • ​Media report: “Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease  progression” by EureKAlert, MedicalXpress, Newswise, ScienceDaily, UK Today News, and MIRAGE News.​

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  • Hu D, Sun SY, Magpusao A, Fedorov Y, Thompson M, Wang BL, Lundberg K, Adams D and Qi X, Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease. Nature Communications, 2021 Sep 6;12(1):5305. PMID: 34489447 

    • Media report: Small-Molecule Suppression of Calpastatin Degradation Reduces Neuropathology in Models of Huntington’s Disease by Harington Discovery Institute News​

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  • Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances.  2020 Dec 4;6(49):eabb8680. PMID: 33277246

    • ​Media report: “New pathway in Alzheimer’s disease provides an earlier target for potential therapies” by EureKAlert, The Medical News, MedicalXpress and Newswise; “A novel Alzheimer’s disease marker-coming early in progression of the condition-could open significant new fronts of research into possible therapies” by The daily of Case Western Reserve University

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  • ​Hu D, Sun XY, Zarabi S, Hong YN, Schimmer A, Liao XD, Ford CP, Luo Y, Qi X, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica, 2019 Jun;137(6):939-960. PMID: 30877431

    • Media report: Alpha-Synuclein Impairs ClpP Enzyme, Causing Mitochondrial Damage – Parkinson’s News Today​

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  • Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7:12646. PMID: 27561680

    • Media reports: Scientists develop therapeutic protein, protect nerve cells from Huntington's disease.   -- Science Daily, EurekAlert/AAAS, NewsWise, NewsMedical, Alzforum​

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  • Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88. PMID: 24231356

    • ​​​​​Comment in: Hope for Huntington's disease? A novel approach for disease modification. Mov Disord. 2014 Aug;29(9):1117.

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  • Su YC and Qi X*. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet. 2013 Nov 15;22(22): 4545-61.  PMID: 23813973  

    • Commentary by Nature Review Neurology: ‘Defective mitochondrial dynamics in the hot seat—a therapeutic target common to many neurological disorders?’  2013 Aug;9(8): 417. PMID: 23877644.

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