Publications after joining CWRU (*, Corresponding Author)

Year 2021 

Mahajan M., Lu B., Bharambe N., Shang YT., Mandal A., Wang RH., Boatz J., van der Wel P., Buck M., Qi X, Ramachandran, R. Structural and mechanistic bases of Drp1-cardiolipin interactions in mitochondrial fission.  Proc Natl Acad Sci U S A, in press.  

 

Hu D, Liu ZR and Qi X, UPRmt activation protects against MPP+-induced toxicity in a cell culture model of Parkinson’s disease. Biochem Biophys Res Commun., in press

Year 2020 

Hu Y, Yang C, Amorim T, Maqbool M, Lin J, Li C, Fang C, Xue L, Kwart A, Fang H, Yin M, Janocha AJ, Tsuchimoto D, Nakabeppu Y, Jiang X, Mejia-Garcia A, Anwer F, Khouri J, Qi X, Zheng QY, Yu JS, Yan S, LaFramboise T, Anderson KC, Herlitz LC, Munshi NC, Lin J, Zhao J. Cisplatin-mediated upregulation of APE2 binding to MYH9 provokes mitochondrial fragmentation and acute kidney injury. Cancer Res. 2020 Dec 7;. doi: 10.1158/0008-5472.CAN-20-1010. 

 

Dudman J and Qi X*, Stress granule dysregulation in Amyotrophic lateral sclerosis. Front Cell Neurosci. 2020 Nov 17;14:598517  

 

Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X*, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances.  2020 Dec 4;6(49):eabb8680.  

 

Jishi A, Qi X, and Miranda H, Implications of mRNA translation dysregulation for neurological disorders. Seminars in Cell and Developmental Biology, 2020, in press

 

Hu D and Qi X*, Quantifying Drp1-Mediated Mitochondrial Fission by Immunostaining in Fixed Cells. Methods Mol Biol, 2020;2159:197-204. doi: 10.1007/978-1-0716-0676-6_15.

Hu D and Qi X*, Measuring Drp1 Activity in Mitochondrial Fission In Vivo. Methods Mol Biol, 2020; 2159:189-195. doi: 10.1007/978-1-0716-0676-6_14.

 

 

Year 2019

Zhao YY, Sun XY, Hu D, Prosdoci D, Jain M, Hoppel C, Ramachandran R, Qi X*, ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation with bioenergetics defects. Nature Communications, 2019, Mar 26;10(1):1371. 

Hu D, Sun XY, Zarabi S, Hong YN, Schimmer A, Liao XD, Ford CP, Luo Y, Qi X*, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica, 2019 Mar 15. doi: 10.1007/s00401-019-01993-2. 

Zhang XW, Hu D, Shang YT and Qi X*, Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases. BBA-Molecular Basis of Disease, 2019, Mar 18. pii: S0925-4439(19)30078-X. 

Fu ZX, Liu F, Jin B, Liu C, Jiang Y, Tang M, and Qi X* and Guo X*. Mutant Huntingtin inhibits mitochondrial unfolded protein response by regulating ABCB10 mRNA stability. BBA-Molecular Basis of Disease, 2019 Feb 22. pii: S0925-4439(19)30067-5. 

Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LH, Bechara LRG, Lima VW, Queliconi BB, Disatnik MH, Dourado PM, Kowaltowski AJ, Mochly-Rosen D. Selective antagonism of mitofusin 1-bIIPKC association, SAMbA, is sufficient to improve heart failure outcome. Nature Communications, 2019 Jan 18;10(1):329.

Year 2018

Zhao YY, Sun XY and Qi X*, Inhibition of Drp1 activation reduces mitochondrial damage and neuropathology in zQ175 knock-in mouse model of Huntington’s disease. Biochem Biophys Res Commun., 2018 Dec 9;507(1-4):319-323.

Lu B, Kennedy B, Clinton RW, Wang E, McHugh D, Stepanyants N, Macdonald PJ, Jason A. Mears JA, Qi X and Ramachandran R., Steric interference from intrinsically disordered polypeptide regions controls dynamin-related protein 1 self-assembly during mitochondrial fission. Sci Rep.,  2018 Jul 18;8(1):10879.

Roe AJ and Qi X*, Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington’s disease. Biochem Biophys Res Commun., 2018, Jan 24.

Year 2017

Luo FC, Herrup K, Qi X* and Yang Y*, Inhibition of Drp1 hyperactivation reduces death of oligodendrocytes and enhances functional recovery in experimental models of multiple sclerosis. Exp Neurol., 2017 Feb 24;292:21-34.  

Qi X*, eIF2alpha links mitochondrial dysfunction to dendritic degeneration. J Cell Biol., 2017 Mar 6;216(3):555-557.  

Guo X and Qi X*, VCP and UBXD1 cooperate to degrade mitochondrial outer membrane protein Mcl1 in model of Huntington’s disease. BBA-Molecular Basis of Disease, 2017 Feb; 1863(2):552-559.  

Year 2016

Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X*, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.  

Disatnik M, Joshi A, Saw N, Shamloo M, Qi X, and Mochly-Rosen D. Potential biomarkers to follow the progression and treatment response of Huntington’s disease. J Exp Med. 2016 Nov 14;213(12):2655-2669.  

Filichia E, Hoffer B, Qi X*, Luo Y*, Inhibition of Drp1 mitochondrial translocation provides neuronal protection in dopaminergic system in a Parkinson’s disease model induced by MPTP. Sci Rep., 2016 Sep 13.  

Qi X, Davis B, Chiang YH, Filichia E, Barnett A, Greig N, Hoffer B, Luo Y, Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson’s disease model. J Neurochem, 2016 Sep;138(5):746-57.

Klionsky DJ, Abdelmohsen K, Abe A, ··· , Qi X, ··· et al, Guidelines for the use and interpretation of assays for minitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.  

Clinton RW, Francy CA, Ramachandran R, Qi X, Mears JA. Dynamin-Related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-Anchored Mitochondrial Fission Factor. J Biol Chem., 2016 Jan 1;291(1):478-92.  

Macdonald PJ, Francy CA, Stepanyants N, Lehman L, Baglio A, Mears JA, Qi X, Ramachandran R. Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity. J Biol Chem., 2016 Jan 1;291(1):493-507.  

Year 2015

Luo Y, Hoffer A, Hoffer B, Qi X*, Mitochondria: a therapeutic target for Parkinson’s disease? International Journal of Molecular Sciences, 2015 Sep 1;16(9):20704-20730. 

Stepanyants N, Macdonald P, Francy CA, Mears J, Qi X and Ramachandran R, Cardiolipin reorganization and phase transition induced by dynamin-related protein 1 promotes mitochondrial membrane fission, Mol Biol Cell, 2015 Sep 1;26(17):3104-16.  

Filichia E, Shen H, Zhou X, Qi X, Jin K, Greig N, Hoffer B, Luo Y, Forebrain neuronal specific abalation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience. 2015 Mar 13.  

Su YC, Guo X and Qi X*, Threonine56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. BBA-Molecular Basis of Disease, 2015 Jan;1852(1):12-21.  

Year 2014

Guo X, Sesaki H and Qi X*. Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J., 2014 Jul 1;461(1):137-46.  

Macdonald PJ, Stepanyants N, Mehrotra N, Mears JA, Qi X, Sesaki H, Ramachandran R, A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell., 2014 Jun 15;25(12):1905-15.  

Year 2013

Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X*, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.  

Su YC and Qi X*. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet. 2013 Nov 15;22(22): 4545-61. PMID: 23813973. 

Mochly-Rosen D, Disatnik M and Qi X, The challenge in translating basic research discoveries to treatment of Huntington’s disease. Rare Dis. 2014 Mar 31;2:e28637. PMID: PMC4091548.  

Disatnik M, Ferreira J, Campos JC, Gomes KS, Dourado P, Qi X, and Mochly-Rosen D, Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.  J Am Heart Assoc., 2013 Oct 8;2(5):e000461.  

Chang XH, Liang LN, Zhan LB, Lu XG, Shi X, Qi X, Feng ZL, Wu MJ, Sui H, The effect of Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline. BMC Complement Altern Med, 2013 Jul 6; 13:161.

Qi X*, Qvit N, Su YC and Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci. 2013 Feb 1;126 (Pt 3): 789-802.  

Su YC and Qi X*. Impairment of Mitochondrial Dynamics: a target for the treatment of neurological disorders? Future Neurology, 2013, May 8; 3: 333-346.