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Publications after joining CWRU (*, Corresponding Author)

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  • Hu D, Sun X and Qi X*., Blocking ClpP/α-synuclein interaction mitigates mitochondrial damage and α-synuclein related neuropathology. BioRxiv 2025, Feb 20:2025.02.16.638540. doi: 10.1101/2025.02.16.638540. PMID: 40027699.  

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  • McGill Percy K, Liu ZR and Qi X*., Mitochondrial dysfunction in Alzheimer's disease: Guiding the path to targeted therapies.  Neurotherapeutics, 2025 Jan 17:e00525. doi: 10.1016/j.neurot.2025.e00525. PMID: 39827052

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  • Cho WJ, Shang YT, Patil S, Qi X* and Jena BP*., Reprogramming the neuronal secretory and metabolic machinery using correctors for Alzheimer’s therapy. *, co-corresponding author, bioRxiv, 2024, https://doi.org/10.1101/2024.11.09.622805. 

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  • Jishi A, Hu D, Shang YT, Wang RH, Gunzler AS and Qi X*., BCKDK loss impairs mitochondrial complex I activity and promotes alpha-synuclein aggregation in models of Parkinson’s disease. Acta Neuropathologica Communication, 2024 Dec 21;12(1):198. doi: 10.1186/s40478-024-01915-8. PMID: 39709505

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  • Wang W, Wang QQ, Qi X, Gurney M, Perry G, Volkow ND, Davis PB, Kaelber D and Xu R., Associations of semaglutide with first-time diagnosis of Alzheimer’s disease in patients with type 2 diabetes: target trial emulation using nationwide real-world data in the US. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. 2024 Oct 24. doi: 10.1002/alz.14313. PMID: 39445596

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  • ​Sridharan PS, Miller E, Kee T, Chakraborty S, Hu D, Tripathi SJ, Koh Yeojung, Chaubey K, Dhar M, Vazquez-Rosa E, Shin MK, Alvarado RA, Barker S, Franke K, Cintron-Perez CJ, Flanagan M, Castellani RJ, Gefen T, Wilson BM, Fujioka H, Woo JA, Kang D, Paul BD, Qi X* and Pieper AA*, Early transient inhibition of excessive mitochondrial fission after brain injury blocks transition to chronic neurodegenerative disease. *, co-corresponding author. Cell Reports Medicine, 2024 Sep 17;5(9):101715. PMID: 39241772​

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  • Yilmaz, S, Pereira Lopes FBT, Schlatzer D, Wang RH, Qi X, Koyuturk M and Chance M., Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome.  iScience, 2024 Sep 13;27(10):110941. PMID: 39391719.

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  • Wallach I, Morrison A, …, Qi X, …, Heifets A., AI is a viable alternative to high throughput screening: a 318-target study.  Scientific report, 2024 Apr 2;14(1):7526. PMID: 38565852

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  • Pereira Lopes F, Schlatzer D, Li MZ, Yilmaz S, Wang RH, Qi X, Ayati M, Koyuturk M, Chance RM*, Methionine Sulfoxide Speciation in Mouse Hippocampus Revealed by Global Proteomics Exhibits Age and Alzheimer’s Disease Dependent Changes Targeted to Mitochondrial and Glycolytic Pathways. Int J Mol Sci. 2024 Jun 13;25(12):6516. PMID: 38928221

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  • Pérez-Jover I, Rochon K, Hu D, Madan Mohan P, Santos-Perez I, Ormaetxea J, Manuel Martinez Galvez J, Agirre J, Qi X, Mears JA, Shnyrova AV, and Ramachandran R., Allosteric control of dynamin-related protein 1-catalyzed mitochondrial and peroxisomal fission through a conserved disordered C-terminal Short Linear Motif. Nature Communications, 2024 Jan 2;15(1):52. PMID: 38168038

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  • Barone C and Qi X*, Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target. Cells, 2023 Jun 2;12(11):1536. PMID: 37296656 

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  • Shang YT, Sun XY, Chen XQ, Wang QQ, Wang EJ, Miller M, Xu R, Pieper AA and Qi X*, A CHCHD6-APP axis connects amyloid and mitochondrial dysfunction in Alzheimer's disease, Acta Neuropathol​, 2022 Nov;144(5):911-938. PMID: 36104602 

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  • Blasco Tavares Pereira Lopes F, Schlatzer D, Wang RH, Li XL, Feng E, Koyuturk M, Qi X, Chance M., Temporal and sex-linked protein expression dynamics in a familial model of Alzheimer’s Disease, Molecular & Cellular Proteomics, 2022 Sep;21(9):100280. PMID: 35944844

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  • Wang S and Qi X*, The putative role of astaxanthin in neuroinflammation modulation: mechanisms and therapeutic potential. Frontier in Pharmacology. 2022 Jun 24;13:916653. PMID: 35814201

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  • Zheng CL, Fillmore RN, Ramos-Cejudo J, Brophy M, Osorio R, Gurney ME, Qiu QQ, Au R, Perry G, Dubreuil M, Chen SG, Qi X, Davis PB, Do N, Xu R, Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score-matched retrospective cohort study in US veterans. Alzheimer’s & Dementia, 2022 Jun;18(6):1248-1259. PMID: 34569707.

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  • Jishi A and Qi X*, Altered Mitochondrial Protein Homeostasis and Proteinopathies, Frontiers in Molecular Neuroscience, 2022 Apr 27;15:867935. PMID: 35571369

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  • Zhao YY#, Hu D#, Wang RH#, Sun XY, Ropelewski P, Hubler Z, Lundberg K, Wang QQ, Adams D, Xu R, and Qi X*, ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models by impairing brain cholesterol turnover. Nature Communications, 2022 Mar 2;13(1):1121. PMID: 35236834. (#, co-first author)    

    • ​Media report: “Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease  progression” by EureKAlert, MedicalXpress, Newswise, ScienceDaily, UK Today News, and MIRAGE News.​​​​​​

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  • Jobava R, Mao Y, Guan B, Hu D, Krokowski D, Chen CW, Shu E, Chukwurah E, Wu J, Gao ZF, Zagore L, Merrick WC, Trifunovic A, Hsieh AC, Waladkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi D, Qian SB, and Hatzoglou M, Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Molecular Cell.  2021 Oct 21;81(20):4191-4208.e8. PMID: 34686314

 

  • Wang Q, Davis PB, Qi X, Chen SG, Gurney ME, Perry G, Doraiswamy MP, Xu R. Gut-microbiota-microglia-brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization. Alzheimer's Research & Therapy.  2021 Oct 20;13(1):177. PMID: 34670619

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  • Mahajan M, Bharambe N, Shang Y, Lu B, Mandal A, Madan Mohan P, Wang R, Boatz JC, Manuel Martinez Galvez J, Shnyrova AV, Qi X, Buck M, van der Wel PCA, Ramachandran R. Structural and mechanistic bases of Drp1-cardiolipin interactions in mitochondrial fission.  Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2023079118. PMID: 34261790

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  • Hu D, Liu ZR and Qi X*, Mitochondrial quality control strategies: potential therapeutic targets for neurodegenerative diseases? Frontiers in Neuroscience, 2021 Nov 12;15:746873. PMID: 34867159

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  • Hu D, Liu ZR and Qi X*, UPRmt activation protects against MPP+-induced toxicity in a cell culture model of Parkinson’s disease. Biochem Biophys Res Commun., 2021 Jun 30;569:17-22. PMID: 34216993

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  • Jishi A, Qi X, and Miranda H, Implications of mRNA translation dysregulation for neurological disorders. Semin Cell Dev Biol. 2021 Jun;114:11-19. PMID: 34024497 

 

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  • Hu D and Qi X*, Quantifying Drp1-Mediated Mitochondrial Fission by Immunostaining in Fixed Cells. Methods Mol Biol, 2020;2159:197-204. PMID: 32529373

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  • Hu D and Qi X*, Measuring Drp1 Activity in Mitochondrial Fission In Vivo. Methods Mol Biol, 2020; 2159:189-195. PMID: 32529372

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  • Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X*, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances.  2020 Dec 4;6(49):eabb8680.  PMID: 33277246 

    • Media report: “New pathway in Alzheimer’s disease provides an earlier target for potential therapies” by EureKAlert, The Medical News, MedicalXpress and Newswise; “A novel Alzheimer’s disease marker-coming early in progression of the condition-could open significant new fronts of research into possible therapies” by The daily of Case Western Reserve University

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  • Dudman J and Qi X*, Stress granule dysregulation in Amyotrophic lateral sclerosis. Front Cell Neurosci. 2020 Nov 17;14:598517.  PMID: 33281563

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  • Zhao YY, Sun XY, Hu D, Prosdoci D, Jain M, Hoppel C, Ramachandran R, Qi X*, ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation with bioenergetics defects. Nature Communications, 2019, Mar 26;10(1):1371. PMID: 30914652

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  • Hu D, Sun XY, Zarabi S, Hong YN, Schimmer A, Liao XD, Ford CP, Luo Y, Qi X*, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica, 2019 Mar 15.  PMID: 30877431

    • Media report: Alpha-Synuclein Impairs ClpP Enzyme, Causing Mitochondrial Damage – Parkinson’s News Today

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  • Zhang XW, Hu D, Shang YT and Qi X*, Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases. BBA-Molecular Basis of Disease, 2019, Mar 18. pii: S0925-4439(19)30078-X. PMID: 30898538

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  • Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LH, Bechara LRG, Lima VW, Queliconi BB, Disatnik MH, Dourado PM, Kowaltowski AJ, Mochly-Rosen D. Selective antagonism of mitofusin 1-bIIPKC association, SAMbA, is sufficient to improve heart failure outcome. Nature Communications, 2019 Jan 18;10(1):329. PMID: 30659190

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  • Fu ZX, Liu F, Jin B, Liu C, Jiang Y, Tang M, and Qi X* and Guo X*. Mutant Huntingtin inhibits mitochondrial unfolded protein response by regulating ABCB10 mRNA stability. BBA-Molecular Basis of Disease, 2019 Feb 22. PMID: 30802639

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  • Roe AJ and Qi X*, Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington’s disease. Biochem Biophys Res Commun., 2018 Feb 5;496(2):706-711. PMID: 29397067 

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  • Lu B, Kennedy B, Clinton RW, Wang E, McHugh D, Stepanyants N, Macdonald PJ, Jason A. Mears JA, Qi X and Ramachandran R., Steric interference from intrinsically disordered polypeptide regions controls dynamin-related protein 1 self-assembly during mitochondrial fission. Sci Rep.,  2018 Jul 18;8(1):10879. PMID: 30022112 

 

  • Zhao YY, Sun XY and Qi X*, Inhibition of Drp1 activation reduces mitochondrial damage and neuropathology in zQ175 knock-in mouse model of Huntington’s disease. Biochem Biophys Res Commun., 2018 Dec 9;507(1-4):319-323. PMID: 30449600​

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  • Qi X*, eIF2alpha links mitochondrial dysfunction to dendritic degeneration. J Cell Biol., 2017 Mar 6;216(3):555-557. PMID: 28209643

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  • Luo FC, Herrup K, Qi X* and Yang Y*, Inhibition of Drp1 hyperactivation reduces death of oligodendrocytes and enhances functional recovery in experimental models of multiple sclerosis. Exp Neurol., 2017 Feb 24;292:21-34.  PMID: 28238799 

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  • Guo X and Qi X*, VCP and UBXD1 cooperate to degrade mitochondrial outer membrane protein Mcl1 in model of Huntington’s disease. BBA-Molecular Basis of Disease, 2017 Feb; 1863(2):552-559.  PMID: 27913212

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  • Filichia E, Hoffer B, Qi X*, Luo Y*, Inhibition of Drp1 mitochondrial translocation provides neuronal protection in dopaminergic system in a Parkinson’s disease model induced by MPTP. Sci Rep., 2016 Sep 13;6:32656. PMID: 27619562

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  • Qi X, Davis B, Chiang YH, Filichia E, Barnett A, Greig N, Hoffer B, Luo Y, Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson’s disease model. J Neurochem, 2016 Sep;138(5):746-57. PMID: 27317935

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  • Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X*, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.  PMID: 27561680 

    • Media reports: Scientists develop therapeutic protein, protect nerve cells from Huntington's disease.   -- Science Daily, EurekAlert/AAAS, NewsWise, NewsMedical, Alzforum

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  • Disatnik M, Joshi A, Saw N, Shamloo M, Qi X, and Mochly-Rosen D. Potential biomarkers to follow the progression and treatment response of Huntington’s disease. J Exp Med. 2016 Nov 14;213(12):2655-2669.  PMID: 27821553

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  • Klionsky DJ, Abdelmohsen K, Abe A, ··· , Qi X, ··· et al, Guidelines for the use and interpretation of assays for minitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.  PMID: 26799652

 

  • Clinton RW, Francy CA, Ramachandran R, Qi X, Mears JA. Dynamin-Related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-Anchored Mitochondrial Fission Factor. J Biol Chem., 2016 Jan 1;291(1):478-92.  PMID: 26578514

 

  • Macdonald PJ, Francy CA, Stepanyants N, Lehman L, Baglio A, Mears JA, Qi X, Ramachandran R. Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity. J Biol Chem., 2016 Jan 1;291(1):493-507.  PMID: 26578513

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  • Luo Y, Hoffer A, Hoffer B, Qi X*, Mitochondria: a therapeutic target for Parkinson’s disease? International Journal of Molecular Sciences, 2015 Sep 1;16(9):20704-20730. PMID: 26340618

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  • Stepanyants N, Macdonald P, Francy CA, Mears J, Qi X and Ramachandran R, Cardiolipin reorganization and phase transition induced by dynamin-related protein 1 promotes mitochondrial membrane fission, Mol Biol Cell, 2015 Sep 1;26(17):3104-16. PMID: 26157169

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  • Filichia E, Shen H, Zhou X, Qi X, Jin K, Greig N, Hoffer B, Luo Y, Forebrain neuronal specific abalation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience. 2015 Jun 4;295:1-10. PMID: 25779964.  

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  • Su YC, Guo X and Qi X*, Threonine56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. BBA-Molecular Basis of Disease, 2015 Jan;1852(1):12-21.  PMID: 25446991 

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  • Guo X, Sesaki H and Qi X*. Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J., 2014 Jul 1;461(1):137-46.  PMID: 24758576

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  • Macdonald PJ, Stepanyants N, Mehrotra N, Mears JA, Qi X, Sesaki H, Ramachandran R, A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell., 2014 Jun 15;25(12):1905-15.  PMID: 24790094.

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  • Mochly-Rosen D, Disatnik M and Qi X, The challenge in translating basic research discoveries to treatment of Huntington’s disease. Rare Dis. 2014 Mar 31;2:e28637. PMID: 25054095

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  • Su YC and Qi X*. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet. 2013 Nov 15;22(22): 4545-61.  PMID: 23813973  

    • Commentary by Nature Review Neurology: ‘Defective mitochondrial dynamics in the hot seat—a therapeutic target common to many neurological disorders?’  2013 Aug;9(8): 417. PMID: 23877644.

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  • Disatnik M, Ferreira J, Campos JC, Gomes KS, Dourado P, Qi X, and Mochly-Rosen D, Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.  J Am Heart Assoc., 2013 Oct 8;2(5):e000461. PMID: 24103571.

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  • Chang XH, Liang LN, Zhan LB, Lu XG, Shi X, Qi X, Feng ZL, Wu MJ, Sui H, The effect of Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline. BMC Complement Altern Med, 2013 Jul 6; 13:161.

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  • Su YC and Qi X*. Impairment of Mitochondrial Dynamics: a target for the treatment of neurological disorders? Future Neurology, 2013, May 8; 3: 333-346.  

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  • Qi X*, Qvit N, Su YC and Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci. 2013 Feb 1;126 (Pt 3): 789-802.  PMID: 23239023 

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