Qi Laboratory 

- Mitochondria in health and disease

Our laboratory focuses on understanding the roles of mitochondrial quality control and metabolism in neurodegenerative diseases. We use unbiased proteomics and genomics, cellular and molecular biology, patient iPS cells-derived cell culture and diseased animals to investigate the fundamental mechanisms by which mitochondrial impairment contributes to cellular metabolism disturbance and neurodegeneration.


We also utilize rationally designed peptide inhibitors of protein-protein interactions and the high throughput screening approach to developing “mitochondrial medicine” as therapeutic strategies for treating neurodegenerative diseases.

Latest News

  • Nov 2022- Cassandra passed her qualifying exam and will start her PhD journey in the Qi lab. Congratulations!!! 

  • Nov 2022- Jack joined our lab as a PhD graduate student! 

  • Oct 2022-  Cassandra wins the Best Research Presentation Award in the 2022 Recknagel Symposium, Congratulations! 

  • Oct 2022- Congratulations to Di for winning the poster award (First place) in the Department Annual Retreat! 

  • August 2022- Qi lab is awarded Vinney Award for Alzheimer's disease. 

  • June 2022- Dr. Rui Zhang joins our lab as a postdoc scholar. Welcome, Rui! 

  • June 2022- Qi lab is awarded an NIH R01 grant to study MICOS complex dysregulation in Alzheimer's disease.

  • June 2022- Shuai's review paper is accepted for publication! Congratulations! 

  • March 2022- Aya's review paper is accepted. Congratulations! 

  • January 2022- Qi lab is awarded an NIH R01 grant to study oligodendroglial metabolism and white matter degeneration in Alzheimer's disease. 



Selected publications

  • Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances.  2020 Dec 4;6(49):eabb8680.



  • Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.  


  • Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.