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Qi Laboratory 

- Mitochondria in health and disease

Our laboratory studies the role of mitochondrial quality control and metabolism in neurodegenerative diseases. We combine proteomics and genomics, cell and molecular biology, patient-derived iPS cell culture and diseased animals to investigate the underlying mechanisms by which mitochondrial dysfunction contributes to impaired cellular metabolism, immune response and neurodegeneration.

We also use rationally designed peptide inhibitors of protein-protein interactions and high-throughput screening to develop "mitochondrial medicine" as a therapeutic strategy for the treatment of neurodegenerative diseases.

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Science
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Publication
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Team
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Latest News

  • May 2024- Kyle passed PhD qualifying exam and advances to PhD candidacy. Congratulations!  

  • Dec 2023- Sarah Cooke joins our lab as a PhD student. Welcome! 

  • Oct 2023- Dr. Na Liu joins the lab as a postdoc scholar, Welcome! 

  • Jun 2023-  Cassandra's review paper is published! Congratulations! 

  • Feb 2023- Rihua is promoted to Research Scientist. Congratulations!  ​

  • Feb 2023- Yutong stays in the lab for her postdoc training! 

  • Jan 2023- Kyle joins our lab as a PhD graduate student! 

  • Nov 2022- Yutong successfully defensed her thesis for PhD! Congratulations, Dr. Shang! 

  • Nov 2022- Cassandra passed her qualifying exam and will start her PhD journey in the Qi lab. Congratulations!!! 

  • Nov 2022- Jack joined our lab as a PhD graduate student! 

  • Oct 2022-  Cassandra wins the Best Research Presentation Award in the 2022 Recknagel Symposium, Congratulations! 

  • Oct 2022- Congratulations to Di for winning the poster award (First place) in the Department Annual Retreat! 

 

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Selected publications

  • Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances.  2020 Dec 4;6(49):eabb8680.

 

 

  • Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.  

 

  • Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.

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