Our laboratory focuses on understanding the roles of mitochondrial quality control and metabolism in neurodegenerative diseases. We use unbiased proteomics and genomics, cellular and molecular biology, patient iPS cells-derived cell culture and diseased animals to investigate the fundamental mechanisms by which mitochondrial impairment contributes to cellular metabolism disturbance and neurodegeneration.


We also utilize rationally designed peptide inhibitors of protein-protein interactions and the high throughput screening approach to developing “mitochondrial medicine” as therapeutic strategies for treating neurodegenerative diseases.

Latest News


  • December 2021- Dr. Trong Bao Nguyen joins the lab as a postdoc. Welcome!! 

  • November 2021- Dr. Di Hu is promoted to Research Scientist, effective on Nov 1st. Congratulations, Di!! 

  • October 2021- Di and Jack's review paper is accepted for publication! Congratulations!!! 

  • October 2021- Dr. Shuai Wang joins the lab as a postdoc. Welcome! 

  • September 2021- Congratulations to Di, Philip, and Jessica for winning the poster awards in the Department Annual Retreat!  ​​​

  • September 2021- Both Jessica and Aya passed their Ph.D. qualifying exams!  Congratulations!!! 

  • June 2021- Yutong as a co-first author and Rihua as a co-author have the paper accepted by PNAS- A great collaborative outcome! Congratulations! 

  • June 2021- Di and Jack's paper is accepted by BBRC, Congratulations! 

Selected publications

  • Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances.  2020 Dec 4;6(49):eabb8680.



  • Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.  


  • Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.