Our laboratory focuses on understanding the roles of mitochondrial quality control and metabolism in neurodegenerative diseases. We use unbiased proteomics and genomics, cellular and molecular biology, patient iPS cells-derived cell culture and diseased animals to investigate the fundamental mechanisms by which mitochondrial impairment contributes to cellular metabolism disturbance and neurodegeneration.
We also utilize rationally designed peptide inhibitors of protein-protein interactions and the high throughput screening approach to developing “mitochondrial medicine” as therapeutic strategies for treating neurodegenerative diseases.
Science
Publications
Team
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Dec 2020- Aya Jishi wins the Best Academic Performance Award in the Department of Physiology & Biophysics, Congratulations!
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Dec 2020- Jessica Dudman wins the Best Research Presentation Award (2nd place) in the 2020 Recknagel Symposium, Congratulations!
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Oct 2020- Jessica's review paper has been accepted by Frontiers Cellular Neuroscience. Congratulations!
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Oct 2020- Our paper "Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease" has been accepted by Science Advances! Congratulations, lab members!
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Oct 2020- Philip joins the lab as a postdoc. Welcome, Philip!
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Sep 2020- Aya's review paper has been accepted by Seminars in Cell and Developmental Biology!