Qi Laboratory
- Mitochondria in health and disease
Our laboratory studies the role of mitochondrial quality control and metabolism in neurodegenerative diseases. We combine proteomics and genomics, cell and molecular biology, patient-derived iPS cell culture and diseased animals to investigate the underlying mechanisms by which mitochondrial dysfunction contributes to impaired cellular metabolism, immune response and neurodegeneration.
We also use rationally designed peptide inhibitors of protein-protein interactions and high-throughput screening to develop "mitochondrial medicine" as a therapeutic strategy for the treatment of neurodegenerative diseases.
Science
Publication
Team
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Feb 2023- Rihua is promoted to Research Scientist. Congratulations!
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Feb 2023- Yutong stays in the lab for her postdoc training!
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Jan 2023- Kyle joins our lab as a PhD graduate student!
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Nov 2022- Yutong successfully defensed her thesis for PhD! Congratulations, Dr. Shang!
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Nov 2022- Cassandra passed her qualifying exam and will start her PhD journey in the Qi lab. Congratulations!!!
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Nov 2022- Jack joined our lab as a PhD graduate student!
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Oct 2022- Cassandra wins the Best Research Presentation Award in the 2022 Recknagel Symposium, Congratulations!
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Oct 2022- Congratulations to Di for winning the poster award (First place) in the Department Annual Retreat!
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Sep 2022- Yutong's paper "A CHCHD6-APP axis connects amyloid and mitochondrial dysfunction in Alzheimer's disease" was accepted by Acta Neuropathologica! Congratulations, Awesome work!
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August 2022- Qi lab is awarded Vinney Award for Alzheimer's disease.
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June 2022- Dr. Rui Zhang joins our lab as a postdoc scholar. Welcome, Rui!
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June 2022- Qi lab is awarded an NIH R01 grant to study MICOS complex dysregulation in Alzheimer's disease.
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June 2022- Shuai's review paper is accepted for publication! Congratulations!
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March 2022- Aya's review paper is accepted. Congratulations!
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January 2022- Qi lab is awarded an NIH R01 grant to study oligodendroglial metabolism and white matter degeneration in Alzheimer's disease.
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Shang YT, Sun XY, Chen XQ, Wang QQ, Wang EJ, Miller M, Xu R, Pieper AA and Qi X, A CHCHD6-APP axis connects amyloid and mitochondrial dysfunction in Alzheimer's disease. Acta Neuropathologica, 2022 Sep 14. doi: 10.1007/s00401-022-02499-0
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Zhao YY, Hu D, Wang RH, Sun XY, Ropelewski P, Hubler Z, Lundberg K, Wang QQ, Adams D, Xu R and Qi X, ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models by impairing brain cholesterol turnover. Nature Communications, 2022. https://doi.org/10.1038/s41467-022-28769-9
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Hu D, Sun SY, Magpusao A, Fedorov Y, Thompson M, Wang BL, Lundberg K, Adams D and Qi X, Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease. Nature Communications, 2021 12, 5305. https://doi.org/10.1038/s41467-021-25651-y
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Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances. 2020 Dec 4;6(49):eabb8680.
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Zhao YY, Sun XY, Hu D, Prosdoci D, Jain M, Hoppel C, Ramachandran R, Qi X, ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation with bioenergetics defects. Nature Communications, 2019, Mar 26;10(1):1371.
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Hu D, Sun XY, Zarabi S, Hong YN, Schimmer A, Liao XD, Ford CP, Luo Y, Qi X, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica, 2019 Mar 15. doi: 10.1007/s00401-019-01993-2.
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Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.
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Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.