Our laboratory focuses on understanding the roles of mitochondrial quality control and metabolism in neurodegenerative diseases. We use unbiased proteomics and genomics, cellular and molecular biology, patient iPS cells-derived cell culture and diseased animals to investigate the fundamental mechanisms by which mitochondrial impairment contributes to cellular metabolism disturbance and neurodegeneration.
We also utilize rationally designed peptide inhibitors of protein-protein interactions and the high throughput screening approach to developing “mitochondrial medicine” as therapeutic strategies for treating neurodegenerative diseases.
Science
Publications
Team
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October 2021- Di and Jack's review paper is accepted for publication! Congratulations!!!
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October 2021- Dr. Shuai Wang joins the lab as a postdoc. Welcome!
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September 2021- Congratulations to Di, Philip, and Jessica for winning the poster awards in the Department Annual Retreat!
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September 2021- Both Jessica and Aya passed their Ph.D. qualifying exams! Congratulations!!!
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June 2021- Yutong as a co-first author and Rihua as a co-author have the paper accepted by PNAS- A great collaborative outcome! Congratulations!
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June 2021- Di and Jack's paper is accepted by BBRC, Congratulations!
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Hu D, Sun SY, Magpusao A, Fedorov Y, Thompson M, Wang BL, Lundberg K, Adams D* and Qi X*, Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease. Nature Communications, 2021 12, 5305. https://doi.org/10.1038/s41467-021-25651-y
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Zhang XW, Wang RH, Hu D, Sun XY, Fujioka H, Lundberg K, Chan ER, Wang QQ, Xu R, Flanagan ME, Pieper AA, and Qi X, Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease. Science Advances. 2020 Dec 4;6(49):eabb8680.
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Zhao YY, Sun XY, Hu D, Prosdoci D, Jain M, Hoppel C, Ramachandran R, Qi X, ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation with bioenergetics defects. Nature Communications, 2019, Mar 26;10(1):1371.
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Hu D, Sun XY, Zarabi S, Hong YN, Schimmer A, Liao XD, Ford CP, Luo Y, Qi X, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathologica, 2019 Mar 15. doi: 10.1007/s00401-019-01993-2.
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Guo X, Sun XY, Di H, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi UA, Luo Y, Mochly-Rosen D and Qi X, VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease. Nature Communications, 2016 Aug 26;7: 12646.
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Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest., 2013 Dec;123(12):5371-88.